Silhouette MD Tirzepatide Review: Cost, Concierge Support & Honest Verdict (2026)

Silhouette MD is a concierge-style GLP-1 telehealth platform bundling monitoring, expert guidance, and check-ins on every plan — not just a prescription — with prescriptions issued and fulfilled by named clinical partner OpenLoop Health. Every fact here comes from the company's own published program.

What Silhouette MD is

Silhouette MD is a concierge-style GLP-1 telehealth platform, offering compounded semaglutide and tirzepatide in both injectable and oral forms, with concierge-level support — monitoring, expert guidance, and check-ins — included on every plan. Prescriptions are issued and fulfilled by OpenLoop Health, a named clinical infrastructure partner.

What Silhouette MD costs

Transparent published pricing starts at $149/month for semaglutide injection, while tirzepatide runs $299/month and oral options $263-$325/month — priced above many compounded competitors here.

The brand-vs-compounded question

Silhouette MD dispenses compounded semaglutide and tirzepatide only — no FDA-approved brand-name option. Compounded tirzepatide is pharmacy-made, not itself an FDA-approved finished drug, and was not the specific product studied in the pivotal trials. See our guide to whether compounded tirzepatide is still legal in 2026 for the regulatory picture.

How the care model holds up

Silhouette MD's real strengths: concierge-level support included on every plan — a genuine differentiator from medication-only sellers, both injectable and oral formulations, transparent published pricing for the entry semaglutide tier, and a named clinical fulfillment partner (OpenLoop Health). The trade-offs: tirzepatide and oral options are priced above many compounded competitors, state availability isn't published, and it's a newer brand with limited independent review history. As with any GLP-1 program, weigh the concierge-support premium against lower-cost, medication-only alternatives; tirzepatide carries labeled warnings for acute pancreatitis, gallbladder disease, and a boxed thyroid C-cell tumor warning — see our guides on Zepbound side effects, the gallbladder risk, and the thyroid cancer warning.

Does the drug work? (Separate from the provider)

Judge the provider on price, oversight and disclosure; judge the molecule on its trials. Tirzepatide's are strong — roughly 15–21% of body weight over 72 weeks in SURMOUNT-1¹, and better than semaglutide head-to-head² — but they were run on the brand drug at FDA-approved doses. Our tirzepatide evidence guide has the full picture.

The honest verdict

Silhouette MD's genuinely concierge-level support — monitoring, guidance, and check-ins on every plan — is a real differentiator, but tirzepatide and oral pricing run above budget competitors here. For a similarly supported provider at a lower price, compare it against Rebody Health or CoreAge Rx. See our best tirzepatide providers ranking for the full field.